Studies and Articles

Ozone, one of the most important air pollutants, is a triatomic molecule containing three atoms of oxygen that results in an unstable form due to its mesomeric structure. It has been well-known that ozone has potent ability to oxidize organic compounds and can induce respiratory irritation. Although ozone has deleterious effects, many therapeutic effects have also been suggested. Since last decades, the therapeutic potential of ozone has gained much attention through its strong capacity to induce controlled and moderated oxidative stress when administered in precise therapeutic doses. A plethora of scientific evidence showed that the activation of hypoxia inducible factor-1α (HIF-1a), nuclear factor of activated T-cells (NFAT), nuclear factor-erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE), and activated protein-1 (AP-1) pathways are the main molecular mechanisms underlying the therapeutic effects of ozone therapy. Activation of these molecular pathways leads to up-regulation of endogenous antioxidant systems, activation of immune functions as well as suppression of inflammatory processes, which is important for correcting oxidative stress in diabetes and spinal pain.

Source: Journal of Cellular Physiology

 

Lateral elbow pain is common with a population prevalence of 1%-3%. The study was a comparative trial to validate the efficacy of single injection of platelet-rich plasma (PRP) for tennis elbow as compared with single injections of triamcinolone and placebo (normal saline) over a short term period.

 

CONCLUSION:

Over a short term period, PRP gives better pain relief than triamcinolone or normal saline in tennis elbow which needs to be validated over long term period by further studies.

Patients on warfarin who present with bleeding or who require an urgent procedure are commonly treated with intravenous (IV) vitamin K, which is supplemented with repletion of the vitamin K factors using either plasma or a prothrombin complex concentrate (PCC). In some such cases, use of vitamin K alone could be adequate to achieve acceptable hemostasis.

DOI: 10.1111/trf.14166  View/save citation

Low back pain is one of the painful disorders of higher prevalence. It has several etiologies and surgery may be indicated in the presence of neurological deficits or compression syndromes. However, in up to 40% of cases, patients develop worsening of pain and failed back surgery syndrome (FBSS), which is an important cause of chronic pain with high morbidity and disability. In the last two decades, ozone has been shown to be a new therapeutic option for FBSS due to its analgesic and anti-inflammatory properties.

 

Our results suggest that epidural ozone therapy can be a treatment option in FBSS to reduce the intensity of the pain.

Objective. Treatment of scleroderma is challenging and limited. The aim of our study was to evaluate the usefulness of thermography in assessment of the clinical condition (joints movability and skin thickness) in clinically advanced patients with systemic sclerosis before and after ozone therapy.

BioMed Research International
Volume 2017 (2017), Article ID 5842723, 7 pages
https://doi.org/10.1155/2017/5842723

We report a case of virus-induced acute respiratory distress syndrome (ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection.

Source:  World Journal of Critical Care Medicine

Ozone major autohemotherapy is effective in reducing the symptoms of multiple sclerosis (MS) patients, but its effects on brain are still not clear. In this work, we have monitored the changes in the cerebrovascular pattern of MS patients and normal subjects during major ozone autohemotherapy by using near-infrared spectroscopy (NIRS) as functional and vascular technique. NIRS signals are analyzed using a combination of time, time-frequency analysis and nonlinear analysis of intrinsic mode function signals obtained from empirical mode decomposition technique. Our results show that there is an improvement in the cerebrovascular pattern of all subjects indicated by increasing the entropy of the NIRS signals. Hence, we can conclude that the ozone therapy increases the brain metabolism and helps to recover from the lower activity levels which is predominant in MS patients.

Source: Medical and Biological Engineering & Computing

Neuropathic pain is a complex type of chronic back and/or leg pain (eg, sciatica) usually caused by nerve injury. When a nerve is damaged it may not be able to transmit messages completely or correctly between the injury site and the brain. Neuropathic pain is persistent and is sometimes described as unrelenting, although the intensity and characteristics (eg, dull, sharp, shock-like) of pain may change throughout the day and night.

Scrambler Technology for Neuropathic Pain
Scrambler technology (Calmare® Pain Therapy Treatment) is a non-invasive therapy that treats neuropathic and chronic pain by surface electro-stimulation. Electrode patches are precisely placed on the appropriate skin area, but not directly on the painful area. Rather, the electrode patches are placed on one or more dermatomes. A dermatome is an area of skin served by the fibers of a single spinal nerve root. The dermatomes map the front and back of the body as shown below.

Precise Biophysical Electro-Stimulation
Each electrode patch is connected to the scrambler device by a thin cable. The clinician controls the administration of low doses of electro-stimulation delivered through the patches. The therapy scrambles the pain messages transmitted between the pain site and the brain.

Placement of electrode patches on a patient’s low back

Typically, treatment consists of a series of 10 daily treatments that last 30- to 45-minutes. Patients with neuropathic and chronic back pain are as unique as their pain. Therefore, some patients may benefit by more than 10 treatments and/or may periodically return for individual therapy.

Effectiveness
Some patients report pain relief as early as the first therapy session. However, many patients experience less pain after several scrambler treatments. As the number of treatments increase, the duration of pain relief may be sustained for a longer period of time. Patients who have experienced chronic pain for a shorter amount of time will generally experience faster results.