The CalmareĀ® medical device was developed by Professor Giuseppe Marineo, a researcher and bioengineer and the founder and manager of Delta Research & Development. Delta R&D is the Bioengineering Research Centre affiliated with Tor Vergata University of Rome, Italy. Presently the technology is being utilized in a variety of medical and government environments.

The device uses a multi-processor able to address up to five separate neurons simultaneously allowing us to treat multiple pain areas at the same time by applying surface electrodes to the skin.